| Urinary bisphenol A concentrations and the risk of obesity in Korean adults | |
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| 년도 | 2021 |
| 날짜 | 2021 Jan 15 |
| 페이지 / 학회지명 |
11(1):1603 / Scientific Reports |
| 논문저자 | Shinje Moon 1, Moon Young Seo 2, Kyungho Choi 3, Yoon-Seok Chang 4, Shin-Hye Kim 5, Mi Jung Park 6 |
| Link |
https://www.nature.com/articles/s41598-021-80980-8
220회 연결
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1 Department of Internal Medicine, Kangnam Sacred Heart Hospital, Hallym University Medical Center, Hallym University College of Medicine, Seoul, 07441, Republic of Korea. 2 Department of Pediatrics, Sanggye Paik Hospital, Inje University College of Medicine, 1342, Dongilro, Nowon-gu, Seoul, 01757, Korea. 3 Department of Environmental Health Sciences, Seoul National University, Seoul, 08826, Republic of Korea. 4 Division of Environmental Science and Engineering, Pohang University of Science and Technology (Postech), Pohang, 37673, Republic of Korea. 5 Department of Pediatrics, Sanggye Paik Hospital, Inje University College of Medicine, 1342, Dongilro, Nowon-gu, Seoul, 01757, Korea. S2635@paik.ac.kr. 6 Department of Pediatrics, Sanggye Paik Hospital, Inje University College of Medicine, 1342, Dongilro, Nowon-gu, Seoul, 01757, Korea. PMJ@paik.ac.kr. Abstract This study was aimed to evaluate the association between urinary bisphenol A (BPA) levels and risk of obesity in Korean adults. We analyzed data from the Korean National Environmental Health Survey (KoNEHS) Cycle 2 (2012-2014) and Cycle 3 (2015-2017). A total of 10,021 participants aged ≥ 19 years were included. Urine dilution was corrected by the covariate-adjusted standardization (CAS) method. We performed meta-analysis, logistic regression analysis by matching all covariates with a 1:1 propensity score, and a 4-knot restricted cubic spline plot model to calculate the odds ratios (ORs) for obesity according to natural log-transformed BPA levels. Mean urinary BPA concentration was 1.12 µg/L in KoNEHS Cycle 2 and 1.32 µg/L in Cycle 3. BPA levels were significantly higher among obese adults than among non-obese adults in both KoNEHS Cycles 2 and 3. In pooled data of KoNEHS Cycles 2 and 3, BPA showed significant positive associations with ORs for obesity in both sexes, which were more prominent in females (linear) than in males (non-linear). These associations were confirmed in spline analyses. CAS-applied BPA concentrations were positively associated with obesity in nationwide representative samples of Korean adults. Further studies are warranted to confirm and elucidate the underlying mechanism. |
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