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Distinct signatures of gut microbiome and metabolites associated with significant fibrosis in non-obese NAFLD
년도 2020
날짜 2020 Oct 5
페이지 /
학회지명		 11(1):4982 / Nature Communications
논문저자 Giljae Lee # 1, Hyun Ju You # 1 2 3, Jasmohan S Bajaj 4, Sae Kyung Joo 5, Junsun Yu 1, Seoyeon Park 1, Hyena Kang 1, Jeong Hwan Park 6, Jung Ho Kim 6, Dong Hyeon Lee 5, Seonhwa Lee 7, Won Kim 8, GwangPyo Ko 9 10 11 12
Link 관련링크 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7536225/ 133회 연결
Affiliations
1 Department of Environmental Health Sciences, Graduate School of Public Health, Seoul National University, Seoul, 08826, Republic of Korea.
2 Institute of Health and Environment, Seoul National University, Seoul, 08826, Republic of Korea.
3 Center for Human and Environmental Microbiome, Institute of Health and Environment, Seoul National University, Seoul, 08826, Republic of Korea.
4 Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University and McGuire VA Medical Center, Richmond, VA, 23249, USA.
5 Division of Gastroenterology and Hepatology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul Metropolitan Government Boramae Medical Center, Seoul, 07061, Republic of Korea.
6 Department of Pathology, Seoul National University College of Medicine, Seoul Metropolitan Government Boramae Medical Center, Seoul, 07061, Republic of Korea.
7 Department of Bio-convergence Engineering, Korea University, Seoul, 02841, Republic of Korea.
8 Division of Gastroenterology and Hepatology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul Metropolitan Government Boramae Medical Center, Seoul, 07061, Republic of Korea. drwon1@snu.ac.kr.
9 Department of Environmental Health Sciences, Graduate School of Public Health, Seoul National University, Seoul, 08826, Republic of Korea. gko@snu.ac.kr.
10 Center for Human and Environmental Microbiome, Institute of Health and Environment, Seoul National University, Seoul, 08826, Republic of Korea. gko@snu.ac.kr.
11 KoBioLabs, Inc., Seoul, 08826, Republic of Korea. gko@snu.ac.kr.
12 Bio-MAX/N-Bio, Seoul National University, Seoul, 08826, Republic of Korea. gko@snu.ac.kr.
#Contributed equally.

Abstract
Nonalcoholic fatty liver disease (NAFLD) is associated with obesity but also found in non-obese individuals. Gut microbiome profiles of 171 Asians with biopsy-proven NAFLD and 31 non-NAFLD controls are analyzed using 16S rRNA sequencing; an independent Western cohort is used for external validation. Subjects are classified into three subgroups according to histological spectra of NAFLD or fibrosis severity. Significant alterations in microbiome diversity are observed according to fibrosis severity in non-obese, but not obese, subjects. Ruminococcaceae and Veillonellaceae are the main microbiota associated with fibrosis severity in non-obese subjects. Furthermore, stool bile acids and propionate are elevated, especially in non-obese subjects with significant fibrosis. Fibrosis-related Ruminococcaceae and Veillonellaceae species undergo metagenome sequencing, and four representative species are administered in three mouse NAFLD models to evaluate their effects on liver damage. This study provides the evidence for the role of the microbiome in the liver fibrosis pathogenesis, especially in non-obese subjects.

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