| Adipogenic effects of prenatal exposure to bisphenol S (BPS) in adult F1 male mice | |
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| 년도 | 2020 |
| 날짜 | 2020 Aug 1 |
| 페이지 / 학회지명 |
728:138759 / Science of the Total Environment |
| 논문저자 | Young-Ah Ahn 1, Hwayoung Baek 2, Miso Choi 3, Junbo Park 4, Soo Jin Son 5, Hyun Ju Seo 6, Jaeyun Jung 7, Je Kyung Seong 8, Jaehyouk Lee 9, Sungkyoon Kim 10 |
| Link |
https://www.sciencedirect.com/science/article/abs/pii/S004896972032276…
145회 연결
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1 Department of Environmental Health Sciences, Graduate School of Public Health, Seoul National University, Seoul 08826, Republic of Korea. Electronic address: youngah@snu.ac.kr. 2 Department of Environmental Health Sciences, Graduate School of Public Health, Seoul National University, Seoul 08826, Republic of Korea. Electronic address: hyhy1016@snu.ac.kr. 3 Department of Environmental Health Sciences, Graduate School of Public Health, Seoul National University, Seoul 08826, Republic of Korea. Electronic address: chms1223@snu.ac.kr. 4 Department of Environmental Health Sciences, Graduate School of Public Health, Seoul National University, Seoul 08826, Republic of Korea. Electronic address: junn1207@snu.ac.kr. 5 Laboratory of Developmental Biology and Genomics, Research Institute for Veterinary Science, and BK21 Program for Advanced Veterinary Science, College of Veterinary Medicine, Seoul National University, Seoul 08826, Republic of Korea; Korea Mouse Phenotyping Center, Seoul National University, Seoul 08826, Republic of Korea. Electronic address: dogazi@snu.ac.kr. 6 Laboratory of Developmental Biology and Genomics, Research Institute for Veterinary Science, and BK21 Program for Advanced Veterinary Science, College of Veterinary Medicine, Seoul National University, Seoul 08826, Republic of Korea; Korea Mouse Phenotyping Center, Seoul National University, Seoul 08826, Republic of Korea. Electronic address: shj20@snu.ac.kr. 7 Laboratory of Developmental Biology and Genomics, Research Institute for Veterinary Science, and BK21 Program for Advanced Veterinary Science, College of Veterinary Medicine, Seoul National University, Seoul 08826, Republic of Korea; Korea Mouse Phenotyping Center, Seoul National University, Seoul 08826, Republic of Korea. Electronic address: flandus@snu.ac.kr. 8 Laboratory of Developmental Biology and Genomics, Research Institute for Veterinary Science, and BK21 Program for Advanced Veterinary Science, College of Veterinary Medicine, Seoul National University, Seoul 08826, Republic of Korea; Korea Mouse Phenotyping Center, Seoul National University, Seoul 08826, Republic of Korea. Electronic address: snumouse@snu.ac.kr. 9 Department of Environmental Health Sciences, Graduate School of Public Health, Seoul National University, Seoul 08826, Republic of Korea. Electronic address: frodo21@snu.ac.kr. 10 Department of Environmental Health Sciences, Graduate School of Public Health, Seoul National University, Seoul 08826, Republic of Korea; Institute of Health and Environment, Graduate School of Public Health, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 08826, Republic of Korea. Electronic address: ddram2@snu.ac.kr. Abstract Bisphenol S (BPS) has been increasingly used as a substitute for bisphenol A (BPA), a known endocrine disruptor. Early-life exposure to BPA affects fetal development and the risk of obesity in adolescence and adulthood. However, the effects of fetal exposure BPS in later life are unknown. This study aimed to investigate the effects of prenatal BPS exposure on adiposity in adult F1 mice. Pregnant C57BL/6 N mice were exposed to BPS (0, 0.05, 0.5, 5, and 50 mg/kg/d) via drinking water from gestation day 9 until delivery. Thereafter, two groups of offspring (6 weeks old) were either administered a standard diet (STD) or a high-fat diet (HFD) for 4 weeks until euthanasia. The body weight and gonadal white adipose tissue (gWAT) mass were determined, and the energy expenditure for the adiposity phenotype was computed especially for male mice, followed by histological analysis of the gWAT. Thereafter, the expression levels of adipogenic marker genes (Pparg, Cebpa, Fabp4, Lpl, and Adipoq) were analyzed in the gWAT via reverse-transcription PCR analysis. BPS-exposed male mice displayed apparent gWAT hypertrophy, consistent with the significant increase in adipocyte size in the gWAT and upregulation of Pparg and its direct target genes among HFD mice in comparison with the control mice. These results suggest that prenatal BPS exposure potentially increases the susceptibility to HFD-induced adipogenesis in male adult mice. Keywords: Adipocyte hypertrophy; Adipogenic marker genes; Bisphenol S; Gonadal white adipose tissue; High-fat diet; Prenatal exposure. |
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