| Aggregate exposure assessment using cosmetic co-use scenarios: II. Application and validation for phthalates | |
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| 년도 | 2020 |
| 날짜 | 2020 Oct |
| 페이지 / 학회지명 |
144, 111583 / Food and Chemical Toxicology |
| 논문저자 | Miyoung Lim 1, Kiyoung Lee 2 |
| Link |
https://www.sciencedirect.com/science/article/abs/pii/S027869152030473…
107회 연결
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1 Department of Environmental Health Sciences, Graduate School of Public Health, Seoul National University, Seoul, South Korea. 2 Department of Environmental Health Sciences, Graduate School of Public Health, Seoul National University, Seoul, South Korea; Institute of Health and Environment, Seoul National University, Seoul, South Korea. Electronic address: cleanair@snu.ac.kr. Abstract Aggregate exposure assessments using co-use scenarios could provide more realistic estimations than single product exposure assessment. Co-use scenarios for cosmetic products were determined from a ranking of the frequency of occurrence of co-use patterns and the number of cosmetics used. We conducted aggregate exposure assessments using the co-use scenarios and validated the new methodology by comparing the results to those of a receptor-based aggregate exposure assessment. The aggregate exposures of di(2-ethylhexyl)phthalate (DEHP), di-n-butyl phthalate (DnBP) and diethyl phthalate (DEP) in cosmetics were estimated by co-use scenarios for cosmetics. The co-use scenario-based AED increased with the number of cosmetics in the co-use scenarios, and was higher in female and younger groups. The major contributors in females were facial cream for DEHP, nail polish for DnBP, and shower cologne or perfume for DEP. The major contributors in males were body lotion for DEHP, facial sunscreen for DnBP, and hair styling product for DEP. The distribution of the co-use scenario based AEDs displayed a similar trend to that of the receptor-based AEDs, with the 95th percentiles of the AED slightly underestimated in the co-use scenario. The applied methodology could provide reasonable aggregate exposures with relatively few resources required. Keywords: Aggregate exposure assessment; Co-use; Cosmetic; Phthalate; Receptor-based. |
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