사업성과
연구성과
Ecological Risk Assessment of Pharmaceuticals in the Surface Water Near a Pharmaceutical Manufacturing Complex in Korea
년도 2020
날짜 2020
페이지 /
학회지명		 46(1), 45-64 / Journal of Environmental Health Science
논문저자 Suhyun Park1, 2, Habyeong Kang2, Hyesoo Shin2, Ilhan Ryoo4, Kyungho Choi2, Younglim Kho4, Kyunghwa Park5, Kyungtae Kim5, and Kyunghee Ji3
Link 관련링크 https://www.kci.go.kr/kciportal/ci/sereArticleSearch/ciSereArtiView.kc… 237회 연결
Affiliations
1 Institute of Natural Science, Yongin University
2 School of Public Health, Seoul National University
3 Department of Occupational and Environmental Health, Yongin University
4 Department of Health, Environment & Safety, Eulji University
5 National Institute of Environmental Research

Abstract
Objectives: Limited information is available on the presence and associated ecological risks of pharmaceutical residues in aquatic environments near pharmaceutical manufacturing areas in Korea. In this study, we investigated the current state of pharmaceutical contamination and its associated ecological risks in streams near
a pharmaceutical manufacturing complex.
Methods: Seven pharmaceuticals (acetaminophen, clarithromycin, diclofenac, diphenhydramine, ibuprofen, mefenamic acid and roxithromycin) were measured in water samples collected from the streams near a pharmaceutical manufacturing complex. A predicted no-effect concentration (PNEC) was derived using either the assessment factor method or species sensitivity distribution method. In addition, a hazard quotient for each pharmaceutical was calculated by dividing its measured environmental concentration by its PNEC.
Results: Samples collected downstream from the wastewater treatment plant (WWTP) had higher concentrations
of pharmaceuticals than those collected from the reference site (upstream). Moreover, pharmaceutical concentrations were greater in ambient water than in the final effluent from the WWTP, which suggested that non-point sources were contributing to the contamination of the ambient water environment. Some of the target pharmaceuticals exhibited a hazard quotient >1, indicating that their potential ecological effects on the aquatic environment near the pharmaceutical industrial area should not be ignored.
Conclusion: This study demonstrated that the pharmaceutical manufacturing area was contaminated with residual drugs, and that there was a possible non-point source near the WWTP effluent discharge area. The results of this study will aid in the development of management plans for pharmaceuticals, particularly in hotspots such as pharmaceutical industrial sites and their vicinities.

Keywords: Environmental risk assessment, manufacturing site, occurrence, pharmaceutical, water environment

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