| Respiratory function declines in children with asthma associated with chemucal species of fine particulate matter(PM2.5) in Nagasaki, Japan | |
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| 년도 | 2021 |
| 날짜 | Oct |
| 페이지 / 학회지명 |
20(1):110 / Environmental Health |
| 논문저자 | Yoonhee Kim 1, Eun Ha Park 2, Chris Fook Sheng Ng 3, Yeonseung Chung 4, Kunio Hashimoto 5, Kasumi Tashiro 6, Hideki Hasunuma 7, Masataka Doi 8, Kei Tamura 9, Hiroyuki Moriuchi 5, Yuji Nishiwaki 10, Hwajin Kim 11, Seung-Muk Yi 11, Ho Kim 11, Masahiro Hashi |
| Link |
https://ehjournal.biomedcentral.com/articles/10.1186/s12940-021-00796-…
121회 연결
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1Department of Global Environmental Health, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan. 2Institute of Health and Environment, Seoul National University, Seoul, South Korea. 3School of Tropical Medicine and Global Health, Nagasaki University, Nagasaki, Japan. 4Department of Mathematical Sciences, Korea Advanced Institute of Science and Technology, Daejeon, South Korea. 5Department of Paediatrics, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan. 6Department of Paediatrics, Isahaya General Hospital, Nagasaki, Japan. 7Department of Public Health, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan. 8Kenhoku Healthcare Office, Nagasaki Prefectural Government, Nagasaki, Japan. 9Pharmaceutical Administration Office, Nagasaki Prefectural Government, Nagasaki, Japan. 10Department of Environmental and Occupational Health, School of Medicine, Toho University, Tokyo, Japan. 11Graduate School of Public Health, Seoul National University, Seoul, South Korea. 12School of Tropical Medicine and Global Health, Nagasaki University, Nagasaki, Japan. hashizume@m.u-tokyo.ac.jp. 13Department of Global Health Policy, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan. hashizume@m.u-tokyo.ac.jp. Abstract Background: The differential effects of PM2.5 fractions on children's lung function remain inconclusive. This study aimed to examine whether lung function in asthmatic children was associated with increased PM2.5 fractions in urban areas in Nagasaki prefecture, Japan, where the air pollution level is relatively low but influenced by transboundary air pollution. Methods: We conducted a multiyear panel study of 73 asthmatic children (boys, 60.3%; mean age, 8.2 years) spanning spring 2014-2016 in two cities. We collected self-measured peak expiratory flow (PEF) twice a day and daily time-series data for PM2.5 total mass and its chemical species. We fitted a linear mixed effects model to examine short-term associations between PEF and PM2.5, adjusting for individual and time-varying confounders. A generalized linear mixed effects model was also used to estimate the association for worsening asthma defined by severe PEF decline. Back-trajectory and cluster analyses were used to investigate the long-range transboundary PM2.5 in the study areas. Results: We found that morning PEFs were adversely associated with higher levels of sulfate (- 1.61 L/min; 95% CI: - 3.07, - 0.15) in Nagasaki city and organic carbon (OC) (- 1.02 L/min; 95% CI: - 1.94, - 0.09) in Isahaya city, per interquartile range (IQR) increase at lag1. In addition, we observed consistent findings for worsening asthma, with higher odds of severe PEF decline in the morning for sulfate (odds ratio (OR) = 2.31; 95% CI: 1.12, 4.77) and ammonium (OR = 1.73; 95% CI: 1.06, 2.84) in Nagasaki city and OC (OR = 1.51; 95% CI: 1.06, 2.15) in Isahaya city, per IQR increase at lag1. The significant chemical species were higher on days that could be largely attributed to the path of Northeast China origin (for sulfate and ammonium) or both the same path and local sources (for OC) than by other clusters. Conclusions: This study provides evidence of the differential effects of PM2.5 fractions on lung function among asthmatic children in urban areas, where the Japanese national standards of air quality have been nearly met. Continuous efforts to promote mitigation actions and public awareness of hazardous transboundary air pollution are needed to protect susceptible children with asthma. Keywords: Asthma; Chemical composition; Children; Lung function; Particulate matter. |
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