| Improvement in host metabolic homeostasis and alteration in gut microbiota in mice on the high-fat diet: A comparison of calcium supplements | |
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| 년도 | 2020 |
| 날짜 | 2020 Oct |
| 페이지 / 학회지명 |
136:109495 / Food Research International |
| 논문저자 | Kwang Hyun Cha 1, Jung-Seok Yang 1, Kyung-A Kim 1, Kye-Yoon Yoon 1, Dae-Geun Song 1, Erdenedolgor Erdene-Ochir 1, Kyungsu Kang 1, Cheol-Ho Pan 2, GwangPyo Ko 3 |
| Link |
https://www.sciencedirect.com/science/article/abs/pii/S096399692030520…
92회 연결
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1 KIST Gangneung Institute of Natural Products, Gangneung 25451, Republic of Korea. 2 KIST Gangneung Institute of Natural Products, Gangneung 25451, Republic of Korea. Electronic address: panc@kist.re.kr. 3 Department of Environmental Health Sciences, School of Public Health, Seoul National University, Seoul 08826, Republic of Korea; Center for Human and Environmental Microbiome, Seoul National University, Seoul 08826, Republic of Korea; KoBioLabs, 1 Gwanak-ro, Gwanak-gu, Seoul 08826, Republic of Korea. Electronic address: gko@snu.ac.kr. Abstract Despite the previously reported health benefits of calcium intake for the attenuation of metabolic disease, few studies have investigated the relationships among calcium intake, gut microbiota, and host metabolism. In this study, we assessed the effects of calcium supplementation on host microbial community composition and metabolic homeostasis. Mice were fed a high-fat diet with different calcium concentrations (4 and 12 g/kg) of 2 calcium supplements, calcium carbonate and calcium citrate. Supplementation with the higher concentration of calcium citrate significantly prevented body weight gain and decreased plasma biomarkers for metabolic disorder compared to calcium carbonate supplementation. Both calcium supplementation led to changes in microbial composition, increased propionate production and increased anorexigenic GLP-1 gene expression. The calcium citrate groups also experienced less metabolic endotoxemia. Our findings suggested that calcium supplementation could ameliorate host metabolic disorder caused by a high-fat diet, due to gut microbiota changes as well as decreased intestinal inflammation. Keywords: Calcium carbonate; Calcium citrate; Gut microbiota; In vivo mice experiment; Metabolic homeostasis. |
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