| Roseburia spp. Abundance Associates with Alcohol Consumption in Humans and Its Administration Ameliorates Alcoholic Fatty Liver in Mice | |
|---|---|
| 년도 | 2020 |
| 날짜 | 2020 Jan 8 |
| 페이지 / 학회지명 |
27(1):25-40.e6 / Cell Host and Microbe |
| 논문저자 | Boram Seo 1, Kyungchan Jeon 2, Sunghyun Moon 3, Kiuk Lee 4, Woon-Ki Kim 2, Hyein Jeong 2, Kwang Hyun Cha 5, Mi Young Lim 6, Wondae Kang 7, Mi-Na Kweon 8, Joohon Sung 9, Won Kim 10, Joo-Hong Park 11, GwangPyo Ko 12 |
| Link |
https://www.cell.com/cell-host-microbe/fulltext/S1931-3128(19)30583-9?…
142회 연결
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1 Department of Environmental Health Sciences, Graduate School of Public Health, Seoul National University, Seoul, Korea; School of Biological Sciences, Seoul National University, Seoul, Korea. 2 Department of Environmental Health Sciences, Graduate School of Public Health, Seoul National University, Seoul, Korea. 3 Department of Environmental Health Sciences, Graduate School of Public Health, Seoul National University, Seoul, Korea; KoBioLabs, Inc., Seoul, Korea. 4 KoBioLabs, Inc., Seoul, Korea. 5 Functional Food Center, Korea Institute of Science and Technology (KIST), Gangneung, Korea. 6 Research Group of Healthcare, Korea Food Research Institute, Wanju, Korea. 7 Department of Life Sciences, Pohang University of Science and Technology, Pohang, Korea. 8 Mucosal Immunology Laboratory, Department of Convergence Medicine, University of Ulsan College of Medicine/Asan Medical Center, Seoul, Korea. 9 Department of Epidemiology, Graduate School of Public Health, Seoul National University, Seoul, Korea. 10 Division of Gastroenterology and Hepatology, Department of Internal Medicine, Seoul Metropolitan Government Seoul National University Boramae Medical Center, Seoul, Korea. 11 School of Biological Sciences, Seoul National University, Seoul, Korea. 12 Department of Environmental Health Sciences, Graduate School of Public Health, Seoul National University, Seoul, Korea; Bio-MAX/N-Bio, Seoul National University, Seoul, Korea; Center for Human and Environmental Microbiome, Institute of Health and Environment, Seoul National University, Seoul, Korea; KoBioLabs, Inc., Seoul, Korea. Electronic address: gko@snu.ac.kr. Abstract Although a link between the gut microbiota and alcohol-related liver diseases (ALDs) has previously been suggested, the causative effects of specific taxa and their functions have not been fully investigated to date. Here, we analyze the gut microbiota of 410 fecal samples from 212 Korean twins by using the Alcohol Use Disorders Identification Test (AUDIT) scales to adjust for host genetics. This analysis revealed a strong association between low AUDIT scores and the abundance of the butyrate-producing genus Roseburia. When Roseburia spp. are administered to ALD murine models, both hepatic steatosis and inflammation significantly improve regardless of bacterial viability. Specifically, the flagellin of R. intestinalis, possibly through Toll-like receptor 5 (TLR5) recognition, recovers gut barrier integrity through upregulation of the tight junction protein Occludin and helps to restore the gut microbiota through elevated expression of IL-22 and REG3γ. Our study demonstrates that Roseburia spp. improve the gut ecosystem and prevent leaky gut, leading to ameliorated ALDs. Keywords: alcohol liver diseases; fat liver diseases; hepatitis; leaky gut; liver steatosis; microbiome; occludin; roseburia. |
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