| Thyroxine-binding globulin, peripheral deiodinase activity, and thyroid autoantibody status in association of phthalates and phenolic compounds with thyroid hormones in adult population | |
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| 년도 | 2020 |
| 날짜 | 2020 Jul |
| 페이지 / 학회지명 |
140, 105783 / Environment International |
| 논문저자 | Sohyeon Choi 1, Min Joo Kim 2, Young Joo Park 2, Sunmi Kim 3, Kyungho Choi 3, Gi Jeong Cheon 4, Yoon Hee Cho 5, Hye Li Jeon 6, Jiyoung Yoo 6, Jeongim Park 7 |
| Link |
https://www.sciencedirect.com/science/article/pii/S0160412019349451
162회 연결
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1 College of Natural Sciences, Soonchunhyang University, Asan, Republic of Korea. 2 Department of Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea. 3 School of Public Health, Seoul National University, Seoul, Republic of Korea. 4 Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea. 5 Center for Environmental Health Sciences, Department of Biomedical and Pharmaceutical Sciences, University of Montana, Missoula, MT, USA. 6 Environmental Health Research Division, National Institute of Environmental Research, Ministry of Environment, Incheon, Republic of Korea. 7 College of Natural Sciences, Soonchunhyang University, Asan, Republic of Korea. Electronic address: jeongim@sch.ac.kr. Abstract Exposure to consumer chemicals such as phthalates and phenolic compounds has been associated with thyroid hormone disruption in humans. However, information related to factors that may influence such associations, e.g., transport and activation of the hormones, and autoimmunity status, is limited. In the present study, we employed a subpopulation of adults (n = 1,254) who participated in the Korean National Environmental Health Survey (KoNEHS) 2015-2017, and associated urinary concentrations of major phthalate metabolites, bisphenol A (BPA), and parabens, with thyroid hormone-related measures, including free and total T3 and T4, TSH, thyroxine-binding globulin (TBG), calculated peripheral deiodinase (DIO) activity, and thyroid autoantibodies of thyroperoxidase (TPO) and thyroglobulin (Tg). Phthalate metabolites were negatively associated with total T4 and free T3, and positively associated with total T3. These observations could be explained by TBG levels and calculated peripheral DIO activity that were positively associated with phthalates exposure. In contrast, BPA was positively associated with total T4 and negatively associated with total T3, without any changes in TBG concentration. Serum TPO and Tg antibodies were not associated with urinary phthalate metabolites and BPA. However, thyroid autoantibody status appeared to modulate the association of some phthalates with thyroid hormones. For parabens, little to negligible association was observed. The results of our observation show potential underlying mechanisms of phthalates-induced thyroid hormone disruption, and suggests the importance of consideration of thyroid autoimmunity status in association studies for thyroid disrupting chemicals. Keywords: Bisphenol A; Endocrine Disruptors; Parabens; Phthalates; Thyroid hormones. |
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