| Adverse effects of perfluoroalkyl acids on fish and other aquatic organisms: A review | |
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| 년도 | 2020 |
| 날짜 | 2020 Mar |
| 페이지 / 학회지명 |
707, 135334 / Science of the Total Environment |
| 논문저자 | Jin Wuk Lee 1, Kyungho Choi 2, Kyunghwa Park 1, Changho Seong 1, Seung Do Yu 1, Pilje Kim 3 |
| Link |
https://www.sciencedirect.com/science/article/abs/pii/S004896971935326…
197회 연결
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1 Research Department of Environmental Health, National Institute of Environmental Research, Incheon 404-708, Republic of Korea. 2 Department of Environmental Health Sciences, Graduate School of Public Health, Seoul National University, Republic of Korea. 3 Research Department of Environmental Health, National Institute of Environmental Research, Incheon 404-708, Republic of Korea. Electronic address: Newchem@korea.kr. Abstract Perfluoroalkyl acids (PFAAs) have been widely used in many industrial and consumer products. They have been detected ubiquitously in ambient water along with other environmental matrices, and their adverse effects on aquatic organisms have been a subject of active investigation. Here, we intended to summarize and synthesize the existing body of knowledge on PFAA toxicity through an extensive literature review, and shed light on areas where further research is warranted. PFAA toxicity appears to be influenced by the sex and developmental stages of aquatic organisms, but not significantly by exposure route. PFAA-induced aquatic toxicity could be classified as metabolism disturbance, reproduction disruption, oxidative stress, developmental toxicity, thyroid disruption, etc. At the molecular level, these responses can be initiated by key events, such as nuclear receptor activation, reactive oxygen species induction, or interaction with a membrane, followed by a cascade of downstream responses. PFAA-induced toxicity involves diverse metabolic processes, and therefore elucidating crosstalk or interactions among diverse metabolic pathways is a challenging task. In the presence of other chemicals, PFAAs can function as agonists or antagonists, resulting in different directions of combined toxicity. Therefore, mixture toxicity with other groups of chemicals is another research opportunity. Experimental evidence supports the trans-generational toxicity of PFAAs, suggesting that their long-term consequences for aquatic ecosystems should become of concern. A recent global ban of several PFAAs resulted in an increasing dependence on PFAA alternatives. The lack of sufficient toxicological information on this emerging group of chemicals warrant caution and rigorous toxicological assessments. Keywords: Aquatic toxicity; Lipid metabolism; Oxidative stress; PFAA; Reproductive toxicity; Xenobiotic response. |
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